Mercer's 2012 Worldwide Cost of Living Survey listed Winston-Salem as the most affordable in the United States for international workers. They measures "the comparative cost of living for expatriates in 214 major cities around the world. We compare the cost of over 200 items in each location, including housing, transport, food, clothing, household goods and entertainment."
So if you are from abroad, Winston-Salem is a great place for you to establish your international career!
View the survey in detail.